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<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Thank you, yes I am looking for comparison of Orbitrap with High
energy collision cell VS top of the line QTOF but not the Synapt. How about
maintenance, Do you think orbitrap maybe requires less maintenance and maybe
its downtime is less than Q-TOF, Thank you <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<div>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#1F497D'>Najeh Kharbatia </span></i><span
style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#1F497D'>Senior Staff Chemist</span></i><span style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#1F497D'>Analytical Department</span></i><span style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#1F497D'>ISP-Wayne, NJ</span></i><span style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:WST_Swed;
color:#1F497D'><a href="mailto:NKharbatia@Ispcorp.com">NKharbatia@Ispcorp.com</a></span></i><span
style='color:#1F497D'><o:p></o:p></span></p>
</div>
<p class=MsoNormal><span style='color:#1F497D'> </span><span
style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p></o:p></span></p>
<div>
<div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span
style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>
massspecgroup-bounces@lists.stevens.edu
[mailto:massspecgroup-bounces@lists.stevens.edu] <b>On Behalf Of </b>Chan,
Chang-Ching<br>
<b>Sent:</b> Tuesday, April 20, 2010 11:40 AM<br>
<b>To:</b> Dept. of Chemistry and Chemical Biology - Dr. Attygalle's Mass
Spectrometry Discussion Group<br>
<b>Subject:</b> Re: [MassSpecGroup] Orbitrab VS QTOF<o:p></o:p></span></p>
</div>
</div>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Najeh,<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Just wanted to clarify, you are comparing Orbitrap and QTOf and
not Orbitrap vs Synapt (IMS), right? Anyways, I am no expert on both
instruments. However, with my limited experience, I thought the Orbitrap
is better than QToF;<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>1. Mass accuracy of 3 ppm on Orbitrap without reference material
is easily achievable (even for small molecules 200-300 u). One would need
reference spray material for mass correction to achieve that in QToF. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>2. You could easily switch between the analyzers (LTQ to
orbitrap and vice versa) which I thought was useful for scouting experiments.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Disadvantage of Orbitrap;<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>1. I thought the Orbitrap was more expensive than QTof (~50%
more). Consider Synapt if you can afford Orbitrap.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>2. Personally, I prefer Waters software, more user friendly.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Moral of the story, I don't think there will be a bad decision
if you choose one over the other. Both instruments are robust and are the
current benchmark for accurate mass measurements.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>ChangChing<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<div style='border:none;border-left:solid blue 1.5pt;padding:0in 0in 0in 4.0pt'>
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<div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span
style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> massspecgroup-bounces@lists.stevens.edu
[mailto:massspecgroup-bounces@lists.stevens.edu] <b>On Behalf Of </b>Kharbatia,
Najeh<br>
<b>Sent:</b> Monday, April 19, 2010 8:16 PM<br>
<b>To:</b> Dept. of Chemistry and Chemical Biology - Dr. Attygalle's Mass
Spectrometry Discussion Group<br>
<b>Subject:</b> [MassSpecGroup] Orbitrab VS QTOF<o:p></o:p></span></p>
</div>
</div>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Hi All,<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>The company I work for is planning to purchase new MS
instruments. I would appreciate the comment from somebody familiar with both
instruments from operational and capability point view and ease of trouble shoot
and maintenance. Think about disadvantages and the advantages of both
instruments.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>I am just trying to help my colleague at the company making
informative decision by listening to the true users of both instruments<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'>Thank you for your help<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#1F497D'>Najeh Kharbatia
</span></i><span style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#1F497D'>Senior Staff Chemist</span></i><span style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#1F497D'>Analytical Department</span></i><span style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";
color:#1F497D'>ISP-Wayne, NJ</span></i><span style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><i><span style='font-size:10.0pt;font-family:WST_Swed;
color:#1F497D'><a href="mailto:NKharbatia@Ispcorp.com">NKharbatia@Ispcorp.com</a></span></i><span
style='color:#1F497D'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:#1F497D'> </span><o:p></o:p></p>
<p class=MsoNormal> <o:p></o:p></p>
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