[MassSpecGroup] Orbitrab VS QTOF

[Athula Attygalle]

Once properly installed Orbitrap needs no cleaning or maintenance. 
Also, Thermo has a very responsible and friendly sales person, who will 
ensure that it will be trouble free.  Waters has a very inexperienced 
sales and service team.  External calibration and stability is a big 
plus that no other system can match.


Kharbatia, Najeh wrote:


>Thank you, yes I am looking for comparison of Orbitrap with High energy
>collision cell VS top of the line QTOF but not the Synapt. How about
>maintenance, Do you think orbitrap maybe requires less maintenance and
>maybe its downtime is less than Q-TOF, Thank you 
>
> 
>
>Najeh Kharbatia                          
>
>Senior Staff Chemist
>
>Analytical Department
>
>ISP-Wayne, NJ
>
>NKharbatia at Ispcorp.com
>
> 
>
>From: massspecgroup-bounces at lists.stevens.edu
>[mailto:massspecgroup-bounces at lists.stevens.edu] On Behalf Of Chan,
>Chang-Ching
>Sent: Tuesday, April 20, 2010 11:40 AM
>To: Dept. of Chemistry and Chemical Biology - Dr. Attygalle's Mass
>Spectrometry Discussion Group
>Subject: Re: [MassSpecGroup] Orbitrab VS QTOF
>
> 
>
>Najeh,
>
> 
>
>Just wanted to clarify, you are comparing Orbitrap and QTOf and not
>Orbitrap vs Synapt (IMS), right? Anyways, I am no expert on both
>instruments. However, with my limited experience, I thought  the
>Orbitrap is better than QToF;
>
>1. Mass accuracy of 3 ppm on Orbitrap without reference material is
>easily achievable (even for small molecules 200-300 u). One would need
>reference spray material for mass correction to achieve that in QToF. 
>
>2. You could easily switch between the analyzers (LTQ to orbitrap and
>vice versa) which I thought was useful for scouting experiments.
>
> 
>
>Disadvantage of Orbitrap;
>
>1. I thought the Orbitrap was more expensive than QTof (~50% more).
>Consider Synapt if you can afford Orbitrap.
>
>2. Personally, I prefer Waters software, more user friendly.
>
> 
>
>Moral of the story, I don't think there will be a bad decision if you
>choose one over the other. Both instruments are robust and are the
>current benchmark for accurate mass measurements.
>
> 
>
> 
>
>ChangChing
>
> 
>
>From: massspecgroup-bounces at lists.stevens.edu
>[mailto:massspecgroup-bounces at lists.stevens.edu] On Behalf Of Kharbatia,
>Najeh
>Sent: Monday, April 19, 2010 8:16 PM
>To: Dept. of Chemistry and Chemical Biology - Dr. Attygalle's Mass
>Spectrometry Discussion Group
>Subject: [MassSpecGroup] Orbitrab VS QTOF
>
> 
>
>Hi All,
>
> 
>
>The company I work for is planning to purchase new MS instruments. I
>would appreciate the comment from somebody familiar with both
>instruments from operational and capability point view and ease of
>trouble shoot and maintenance. Think about disadvantages and the
>advantages of both instruments.
>
> 
>
>I am just trying to help my colleague at the company making informative
>decision by listening to the true users of both instruments
>
> 
>
>Thank you for your help
>
> 
>
>Najeh Kharbatia                          
>
>Senior Staff Chemist
>
>Analytical Department
>
>ISP-Wayne, NJ
>
>NKharbatia at Ispcorp.com
>
> 
>
>  
>
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--------------------------------------
Prof. Athula Attygalle
Dept of Chemistry and Chemical Biology
Stevens Institute of Technology
Hoboken
NJ 07030
USA