[MassSpecGroup] Orbitrab VS QTOF

[Chan, Chang-Ching]

Najeh,

Just wanted to clarify, you are comparing Orbitrap and QTOf and not Orbitrap vs Synapt (IMS), right? Anyways, I am no expert on both instruments. However, with my limited experience, I thought  the Orbitrap is better than QToF;
1. Mass accuracy of 3 ppm on Orbitrap without reference material is easily achievable (even for small molecules 200-300 u). One would need reference spray material for mass correction to achieve that in QToF.
2. You could easily switch between the analyzers (LTQ to orbitrap and vice versa) which I thought was useful for scouting experiments.

Disadvantage of Orbitrap;
1. I thought the Orbitrap was more expensive than QTof (~50% more). Consider Synapt if you can afford Orbitrap.
2. Personally, I prefer Waters software, more user friendly.

Moral of the story, I don't think there will be a bad decision if you choose one over the other. Both instruments are robust and are the current benchmark for accurate mass measurements.


ChangChing

From: massspecgroup-bounces at lists.stevens.edu [mailto:massspecgroup-bounces at lists.stevens.edu] On Behalf Of Kharbatia, Najeh
Sent: Monday, April 19, 2010 8:16 PM
To: Dept. of Chemistry and Chemical Biology - Dr. Attygalle's Mass Spectrometry Discussion Group
Subject: [MassSpecGroup] Orbitrab VS QTOF

Hi All,

The company I work for is planning to purchase new MS instruments. I would appreciate the comment from somebody familiar with both instruments from operational and capability point view and ease of trouble shoot and maintenance. Think about disadvantages and the advantages of both instruments.

I am just trying to help my colleague at the company making informative decision by listening to the true users of both instruments

Thank you for your help

Najeh Kharbatia
Senior Staff Chemist
Analytical Department
ISP-Wayne, NJ
NKharbatia at Ispcorp.com<mailto:NKharbatia at Ispcorp.com>


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