[MassSpecGroup] Orbitrab VS QTOF

[Kharbatia, Najeh]

Thank you, yes I am looking for comparison of Orbitrap with High energy
collision cell VS top of the line QTOF but not the Synapt. How about
maintenance, Do you think orbitrap maybe requires less maintenance and
maybe its downtime is less than Q-TOF, Thank you 

 

Najeh Kharbatia                          

Senior Staff Chemist

Analytical Department

ISP-Wayne, NJ

NKharbatia at Ispcorp.com

 

From: massspecgroup-bounces at lists.stevens.edu
[mailto:massspecgroup-bounces at lists.stevens.edu] On Behalf Of Chan,
Chang-Ching
Sent: Tuesday, April 20, 2010 11:40 AM
To: Dept. of Chemistry and Chemical Biology - Dr. Attygalle's Mass
Spectrometry Discussion Group
Subject: Re: [MassSpecGroup] Orbitrab VS QTOF

 

Najeh,

 

Just wanted to clarify, you are comparing Orbitrap and QTOf and not
Orbitrap vs Synapt (IMS), right? Anyways, I am no expert on both
instruments. However, with my limited experience, I thought  the
Orbitrap is better than QToF;

1. Mass accuracy of 3 ppm on Orbitrap without reference material is
easily achievable (even for small molecules 200-300 u). One would need
reference spray material for mass correction to achieve that in QToF. 

2. You could easily switch between the analyzers (LTQ to orbitrap and
vice versa) which I thought was useful for scouting experiments.

 

Disadvantage of Orbitrap;

1. I thought the Orbitrap was more expensive than QTof (~50% more).
Consider Synapt if you can afford Orbitrap.

2. Personally, I prefer Waters software, more user friendly.

 

Moral of the story, I don't think there will be a bad decision if you
choose one over the other. Both instruments are robust and are the
current benchmark for accurate mass measurements.

 

 

ChangChing

 

From: massspecgroup-bounces at lists.stevens.edu
[mailto:massspecgroup-bounces at lists.stevens.edu] On Behalf Of Kharbatia,
Najeh
Sent: Monday, April 19, 2010 8:16 PM
To: Dept. of Chemistry and Chemical Biology - Dr. Attygalle's Mass
Spectrometry Discussion Group
Subject: [MassSpecGroup] Orbitrab VS QTOF

 

Hi All,

 

The company I work for is planning to purchase new MS instruments. I
would appreciate the comment from somebody familiar with both
instruments from operational and capability point view and ease of
trouble shoot and maintenance. Think about disadvantages and the
advantages of both instruments.

 

I am just trying to help my colleague at the company making informative
decision by listening to the true users of both instruments

 

Thank you for your help

 

Najeh Kharbatia                          

Senior Staff Chemist

Analytical Department

ISP-Wayne, NJ

NKharbatia at Ispcorp.com

 

  

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